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KMID : 0861020140290030059
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Korea Journal of Herbology
2014 Volume.29 No. 3 p.59 ~ p.70
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Hypoglycemic Effects of Boiled rice made from Unpolished rice, Job’ tear, and Extract From Medicinal Herbs Mixture on Diabetic Rat
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Lee Hyeon-Sun
Kong Hyun-Joo
Lee Eon-Hee
Hwang Su-Jung
Jung Hyeon-A
Kim Mi-Lim
Choi Eun-Mi
Jang Joung-Hyeon
Yang Kyung-Mi
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Abstract
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Objectives : The purpose of this study was to evaluate boiled rice made from unpolished rice, Job`s Tears, and extract from medicinal herbs mixture (HGMCJE) for hypoglycemic effect on STZ-induced diabetic rats.
Methods : In the response of glucose tolerance, control and diabetic rats groups was intubated with glucose and HGMCJE. Furthermore, boiled 100% polished rice (P rice), boiled unpolished rice mixed with white rice and Job`s tears (polished rice:unpolished rice:Job`s tears=60:25:15, UPJ-rice), and UPJ rice made from HGMCJE (HUPJ-rice) were intubated to control and diabetic rats groups, respectively. Then, blood glucose concentration, incremental blood glucose, and area under the curve (ΔAUC) were analyzed in every experimental groups, and these data were used to evaluate glycemic response.
Results : When glucose and p rice were intubated in control and diabetic rats, blood glucose concentration, incremental blood glucose, and incremental response ΔAUC of diabetic groups were significantly increase than control groups. But administraion of a single dose of extract from medicinal herbs mixture and HUPJ-rice in control and diabetic rats inhibited the remarkable increase the level of postprandial blood and ΔAUC at 60, 90, and 120 min.
Conclusions : These results indicate that when intubation of glucose and P rice were out of control on postprandial glycemic response in diabetic rats. But postprandial glycemic response was well-modulated by administrating a single oral dose of HGMCJE and HUPJ-rice. Therefore, HGMCJE can be developed as an effective hypoglycemic agent.
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KEYWORD
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Korean traditional herbal extracts, anti-diabetic, postprandial glycemic response
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